HIC1 Silencing in Triple-Negative Breast Cancer Drives Progression through Misregulation of LCN2
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چکیده
منابع مشابه
Prevention and Epidemiology HIC1 Silencing in Triple-Negative Breast Cancer Drives Progression through Misregulation of LCN2
The tumor suppressor gene HIC1 is frequently deleted or epigenetically silenced in human cancer, where its restorationmay improve cancer prognosis. Here, we report results illuminating howHIC1 silencing alters effect or signals in triple-negative breast cancer (TNBC), which are crucial for its pathogenesis. HIC1 expression was silenced only in TNBC compared with other molecular subtypes of brea...
متن کاملHIC1 silencing in triple-negative breast cancer drives progression through misregulation of LCN2.
The tumor suppressor gene HIC1 is frequently deleted or epigenetically silenced in human cancer, where its restoration may improve cancer prognosis. Here, we report results illuminating how HIC1 silencing alters effect or signals in triple-negative breast cancer (TNBC), which are crucial for its pathogenesis. HIC1 expression was silenced only in TNBC compared with other molecular subtypes of br...
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BACKGROUND Distant metastasis of triple-negative breast cancer (TNBC) to other organs, e.g., the lungs, has been correlated with poor survival rates among breast cancer patients. Therefore, the identification of useful therapeutic targets to prevent metastasis or even inhibit tumor growth of TNBC is urgently needed. Gαh is a novel GTP-binding protein and known as an inactive form of calcium-dep...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2013
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-13-2420